Key result
Left ventricular systolic dysfunction before renal transplantation was associated with an increased risk of cardiac complications (HR 1.8, P=0.01) and all-cause mortality (HR 2.0, P=0.01).
Why the study?
Does left ventricular systolic dysfunction increase the risk of mortality and cardiac complications in renal transplant recipients?
Population
653 recipients of renal allografts who underwent stress SPECT imaging before transplantation.
Comparison
Left ventricular systolic dysfunction at the… vs Normal left ventricular ejection fraction
Design
Cohort
Follow-up
mean 3.01 ± 1.86 years
Authors
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Decreased pretransplant LVEF may identify higher cardiac risk recipients; observational data leave open whether LVEF optimization improves outcomes.
Cohort (n=653)
Does left ventricular systolic dysfunction increase the risk of mortality and cardiac complications in renal transplant recipients?
Hazard Ratio: 1.8
p-value: p=0.01
Left ventricular systolic dysfunction (LVEF ≤45%) prior to renal transplantation is a strong, independent predictor of increased all-cause mortality, cardiac mortality, and nonfatal cardiac events post-transplant.
Siedlecki et al. (2007) conducted a cohort in Renal transplantation (n=653). Left ventricular systolic dysfunction (LVEF <=45%) vs. Normal LVEF was evaluated on Cardiac complications (HR 1.8, p=0.01). Left ventricular systolic dysfunction before renal transplantation was associated with an increased risk of cardiac complications (HR 1.8, P=0.01) and all-cause mortality (HR 2.0, P=0.01).
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