Not too close for comfort: Practical chiral organocatalysts like that shown promote Michael addition reactions of a wide range of trisubstituted carbon nucleophiles to various nitroalkenes, often with nearly perfect stereoselectivity (>99 % ee and >98:2 d.r.). In one step adjacent carbon- or heteroatom-substituted quaternary and tertiary stereocenters are generated from readily available starting materials.
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Li et al. (2004) studied this question.
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