Key result
Prosome RNA selectively inhibits viral mRNA translation without affecting the translation of normal cellular mRNA.
Prosome RNA selectively inhibits viral mRNA translation without affecting normal cellular mRNA.
May offer selective antiviral strategy; leaves open human translation and therapeutic viability.
Prosomes are small cytoplasmic RNP complexes. We present evidence that their RNA is a potential and selective inhibitor of viral mRNA translation while translation of normal cellular mRNA e.g. rabbit globin mRNA or HeLa cell mRNA is not affected.
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Horsch et al. (1985) studied this question. Prosome RNA selectively inhibits viral mRNA translation without affecting the translation of normal cellular mRNA.
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