What question did this study set out to answer?

Investigate how cigarette smoking and subsequent 3- to 4-month smoking cessation alter the pharmacokinetics and metabolic clearance of theophylline.

May 1, 1976Clinical Pharmacology & Therapeutics

Effect of smoking on theophylline disposition

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Authors

SHSusan N. HuntBuffalo General Medical Center WJWilliam J. JuskoUniversity at Buffalo, State University of New York AYAnthony M. YurchakPfizer (United States)

Discussion

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Implication

Pharmacokinetic study demonstrates increased theophylline clearance in cigarette smokers, indicating persistent metabolic enzyme induction even months after smoking cessation.

Key Points

Investigate how cigarette smoking and subsequent 3- to 4-month smoking cessation alter the pharmacokinetics and metabolic clearance of theophylline.
Evaluated theophylline disposition in nonsmokers and heavy smokers (1 to 2 packs/day) before and 3 to 4 months after smoking cessation.
Tracked smoking status and tobacco exposure using serum thiocyanate concentrations.
Smokers demonstrated a shorter theophylline half-life (mean 4.3 ± 1.4 hr vs 7.0 ± 1.7 hr in nonsmokers) and higher clearance (100 ± 44 vs 45 ± 13 ml/min/1.73 m²).
Theophylline body clearance correlated positively with serum thiocyanate levels (r = 0.785, p < 0.001).
Among the 4 of 8 smokers who maintained abstinence for at least 3 months, theophylline elimination rates showed no significant change.

Cite This Study

Hunt et al. (1976) studied this question.

synapsesocial.com/papers/6a655270f269cd094639df01 https://doi.org/10.1002/cpt1976195part1546

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May 1, 1976Clinical Pharmacology & Therapeutics

Effect of smoking on theophylline disposition

View Full Paper

Ask AI

Bookmark

Authors

SHSusan N. HuntBuffalo General Medical Center WJWilliam J. JuskoUniversity at Buffalo, State University of New York AYAnthony M. YurchakPfizer (United States)

Discussion

Member takes

Implication

Pharmacokinetic study demonstrates increased theophylline clearance in cigarette smokers, indicating persistent metabolic enzyme induction even months after smoking cessation.

Key Points

Investigate how cigarette smoking and subsequent 3- to 4-month smoking cessation alter the pharmacokinetics and metabolic clearance of theophylline.
Evaluated theophylline disposition in nonsmokers and heavy smokers (1 to 2 packs/day) before and 3 to 4 months after smoking cessation.
Tracked smoking status and tobacco exposure using serum thiocyanate concentrations.
Smokers demonstrated a shorter theophylline half-life (mean 4.3 ± 1.4 hr vs 7.0 ± 1.7 hr in nonsmokers) and higher clearance (100 ± 44 vs 45 ± 13 ml/min/1.73 m²).
Theophylline body clearance correlated positively with serum thiocyanate levels (r = 0.785, p < 0.001).
Among the 4 of 8 smokers who maintained abstinence for at least 3 months, theophylline elimination rates showed no significant change.

Cite This Study

Hunt et al. (1976) studied this question.

synapsesocial.com/papers/6a655270f269cd094639df01 https://doi.org/10.1002/cpt1976195part1546

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