Why the study?
Does obesity affect the total body clearance of theophylline in smokers and nonsmokers with and without congestive heart failure?
Population
150 adults, including obese and nonobese subjects, smokers and nonsmokers, with and without congestive heart…
Comparison
Theophylline administration vs Nonobese subjects matched for age, sex, and…
Design
Cross-sectional
Authors
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Obesity does not alter theophylline clearance per total body weight in nonsmokers; leaves open prospective validation across smoking and heart failure status.
Does obesity affect the total body clearance of theophylline in smokers and nonsmokers with and without congestive heart failure?
Theophylline maintenance dosing can be based on total body weight in obese patients, regardless of smoking status or the presence of congestive heart failure.
Slaughter et al. (1983) studied this question.
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