Key result
Tailored low-calorie diet linked to ~4 kg weight loss and improved NYHA class in HF.
Why the study?
Obesity is controversially indicated both as a risk factor for developing congestive heart failure and as a positive prognostic factor, with unclear impact of weight loss on clinical outcomes.
Does a tailored low-caloric dietary program improve clinical and instrumental parameters in overweight and obese patients with heart failure?
Observational (n=560)
Does a tailored low-caloric dietary program improve clinical and instrumental parameters in overweight and obese patients with heart failure?
p-value: p=<0.05
A tailored low-caloric diet in overweight and obese patients with heart failure significantly improves NYHA class, blood pressure, and lipid profiles.
Diet-induced weight loss may improve NYHA class and lipids in obese HF; leaves open effects on outcomes and need for RCTs before practice change.
The current scientific data controversially indicate obesity both as a risk factor for developing congestive heart failure (CHF) and a positive prognostic factor. The present study evaluated the impact of weight loss on clinical and instrumental parameters in a selected group of obese patients with CHF. An overall population of 560 HF patients was sub-grouped on the basis of the Body Mass Index (BMI): 8.2% were underweight (BMI<20.7), 63.9% normal weight (BMI: 20.7–27.7), 19.6% overweight (BMI: 27.8–31), and 8.3% obese (BMI>31). Of the 46 overweight and obese patients, 28 (55.2% men, age 51–80 years) accepted a tailored low-caloric dietary program for at least 4 months. The 28 patients belonged to both obese and overweight groups (BMI>27.8) and were in NYHA classes II–III. Mean follow-up was 5 months. The mean loss of body weight was 4 kg in 81.4% of patients, versus 3 kg mean increase in whole (560 patients) population (72.5–75.5 kg). In the 28 patients we recorded a significant (p<0.05) improvement of NYHA class, better control of arterial blood pressure and statistically significant (p<0.05) lowering of total cholesterol and triglyceride levels. Tailored dietetic program may improve clinical and instrumental parameters in patients with CHF.
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Mariotti et al. (2004) conducted an observational in Congestive heart failure and obesity (n=560). Tailored low-caloric dietary program vs. Whole heart failure population (n=560) was evaluated on Clinical and instrumental parameters (NYHA class, arterial blood pressure, total cholesterol, and triglycerides) (p=<0.05). A tailored low-caloric diet in overweight/obese heart failure patients led to a 4 kg mean weight loss vs a 3 kg increase in the whole cohort, and improved NYHA class and blood pressure (p<0.05).
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