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March 27, 2018PLoS MedicineOpen Access

Comorbidity health pathways in heart failure patients: A sequences-of-regressions analysis using cross-sectional data from 10,575 patients in the Swedish Heart Failure Registry

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Key result

Anxiety or depression had the strongest association with worse patient-rated health (mean difference in EQ-VAS score -18.68) and functional limitations among heart failure patients.

Population

10,575 heart failure patients with patient-rated health recorded during first registration in the Swedish…

Design

Cross-sectional

Authors

CLClaire LawsonUniversity of North Carolina at CharlotteISIvonne Solis‐TrapalaKeele UniversityUDUlf DahlströmHeart Failure / Cardiomyopathy

Discussion

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Implication

Comorbidities may worsen HF symptoms and health status; leaves open whether targeting them improves outcomes.

Study Design

Type

Cross-Sectional (n=10,575)

Multicenter

Yes

Structured PICO

P
Population
10,575 heart failure patients from the Swedish Heart Failure Registry with patient-rated health recorded at baseline.
O
Outcome
Patient-rated health measured by EuroQol-5 dimension (EQ-5D) questionnaire and EuroQol visual analogue scale (EQ-VAS)patient reported

Main Result

Mean Difference: -18.68 (95% CI -23.22–-14.14)

Comorbidities in heart failure patients, particularly anxiety/depression and non-cardiovascular conditions, significantly impair patient-rated health through distinct symptom pathways.

Limitations

  • Cross-sectional design limits causal inference
  • Unclear generalisability to other populations
  • Lack of some relevant variables that might impact health such as social status/deprivation, emotional, and spiritual measures
  • Potential misclassification of comorbidities and symptoms due to reliance on clinical recording
  • cross-sectional design
  • unclear generalisability to other populations

Cite This Study

Lawson et al. (2018) conducted a cross-sectional in Heart failure (n=10,575). Anxiety or depression vs. No anxiety or depression was evaluated on Patient-rated health (EQ-VAS score) (MD -18.68, 95% CI -23.22 to -14.14). Anxiety or depression had the strongest association with worse patient-rated health (mean difference in EQ-VAS score -18.68) and functional limitations among heart failure patients.

synapsesocial.com/papers/6a656aa3d8f85b2777d784bfhttps://doi.org/10.1371/journal.pmed.1002540

Topics

Heart failureHFrEF treatment
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