Key result
Knockdown of nNOS expression in the PVN of conscious Wistar rats resulted in a sustained increase in blood pressure (from 95 to 104 mmHg, P<0.05) and >70% activation of renal SNA (P<0.05).
Population
Conscious Wistar rats (n=14)
Comparison
Bilateral microinjection into the… vs Bilateral microinjection into the PVN with a…
Design
Preclinical
Follow-up
18 days post-injection
Authors
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No immediate clinical implications; animal data leave open translation to human hypertension therapies.
p-value: p=<0.05
Endogenous nitric oxide generated by nNOS in the paraventricular nucleus plays a major constitutive role in suppressing long-term renal sympathetic activity and arterial pressure in conscious rats.
McBryde et al. (2017) studied Normotensive (n=14). nNOS knockdown in the PVN via lentiviral vector vs. Mis-sense control vector was evaluated on Blood pressure and renal sympathetic nerve activity (p=<0.05). Knockdown of nNOS expression in the PVN of conscious Wistar rats resulted in a sustained increase in blood pressure (from 95 to 104 mmHg, P<0.05) and >70% activation of renal SNA (P<0.05).
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