Why the study?
Does overexpression of hKir2.1 in the paraventricular nucleus reduce blood pressure and sympathetic activity in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHRs) and normotensive Wistar rats (WKY)
Comparison
Bilateral stereotaxic microinjection of… vs Sham treatment with bilateral PVN…
Design
Preclinical
Follow-up
75 days
Authors
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Hypothesis-generating for PVN-targeted sympathetic modulation in hypertension; leaves open translation to human therapy.
Does overexpression of hKir2.1 in the paraventricular nucleus reduce blood pressure and sympathetic activity in spontaneously hypertensive rats?
Chronic depression of paraventricular nucleus neuronal activity via hKir2.1 overexpression produces sustained hypotension and reduces sympathetic vasomotor tone in spontaneously hypertensive rats.
Geraldes et al. (2013) studied this question.
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