Key result
Bicuculline microinjection into the paraventricular nucleus failed to increase blood pressure and reduced plasma norepinephrine and epinephrine responses by 75% and 68% in hypertensive rats.
Why the study?
Does microinjection of bicuculline or muscimol alter blood pressure and catecholamine responses in renal-wrapped hypertensive rats compared to sham controls?
Population
Rats with bilateral cannulas in the paraventricular nucleus, made hypertensive by a one-kidney, figure eight…
Comparison
Microinjection of bicuculline methiodide or… vs Sham operated control rats receiving the same…
Design
Preclinical
Follow-up
4 days after hypertension surgery
Authors
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Warrants caution extrapolating rat PVN findings to patients; leaves open GABAergic contributions to human hypertension.
Does microinjection of bicuculline or muscimol alter blood pressure and catecholamine responses in renal-wrapped hypertensive rats compared to sham controls?
These data suggest that GABA function in the paraventricular nucleus is reduced in renal wrap hypertension.
Martin et al. (1998) studied Hypertension. Bicuculline methiodide or muscimol microinjection vs. Sham operated control rats was evaluated on Blood pressure, heart rate, and plasma catecholamine concentrations. Bicuculline microinjection into the paraventricular nucleus failed to increase blood pressure and reduced plasma norepinephrine and epinephrine responses by 75% and 68% in hypertensive rats.
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