Why the study?
Does altered GABA-mediated inhibition in the PVN affect renal sympathetic nerve discharge and blood pressure in rats with heart failure?
Population
Rats with heart failure induced by coronary artery ligation, anesthetized with alpha-chloralose and urethane
Comparison
Microinjection of bicuculline or muscimol into… vs Sham-operated control rats
Design
Preclinical
Authors
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May underlie sympathetic overdrive in HF; hypothesis-generating for GABA-targeted interventions in patients.
Does altered GABA-mediated inhibition in the PVN affect renal sympathetic nerve discharge and blood pressure in rats with heart failure?
Reduced GABA-mediated inhibition in the PVN may contribute to the increased sympathetic outflow commonly observed in heart failure.
Zhang et al. (2002) studied this question.
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