Key result
Activation of GABA(A) or GABA(B) receptors in the PVN inhibits the cardiac sympathetic afferent reflex, while blockage of GABA(B) receptors enhances it in rats.
Why the study?
Does activation or blockade of GABA receptors in the paraventricular nucleus regulate the cardiac sympathetic afferent reflex in rats?
Population
Sinoaortic-denervated and cervical-vagotomized rats under urethane and alpha-chloralose anesthesia
Comparison
Bilateral paraventricular nucleus microinjection… vs Baseline state or combined antagonist…
Design
Preclinical
Authors
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Hypothesis-generating for central GABAergic control of sympathetic reflexes; leaves open translation to human cardiovascular therapies.
Does activation or blockade of GABA receptors in the paraventricular nucleus regulate the cardiac sympathetic afferent reflex in rats?
Endogenous GABA in the paraventricular nucleus plays an important role in regulating the cardiac sympathetic afferent reflex in a rat model.
Zhong et al. (2008) studied this question. GABA(A) and GABA(B) receptor agonists and antagonists vs. Baseline was evaluated on Cardiac sympathetic afferent reflex (CSAR) evaluated based on RSNA response to epicardial capsaicin or bradykinin. Activation of GABA(A) or GABA(B) receptors in the PVN inhibits the cardiac sympathetic afferent reflex, while blockage of GABA(B) receptors enhances it in rats.
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