May 1, 2003Experimental PhysiologyOpen Access

Role of GABA and NO in the Paraventricular Nucleus‐Mediated Reflex Inhibition of Renal Sympathetic Nerve Activity Following Stimulation of Right Atrial Receptors in the Rat

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Why the study?

Does right atrial receptor stimulation reduce renal sympathetic nerve activity via GABA in the paraventricular nucleus in anaesthetised Wistar rats?

Population

Anaesthetised Wistar rats

Comparison

Right atrial receptor stimulation via balloon… vs Baseline control

Design

Preclinical

Authors

ZYZhuo YangDalian Medical University JCJohn H. CooteBirmingham City University

Discussion

Member takes

Implication

Hypothesis-generating in rats; leaves open whether PVN GABA mediates human atrial-renal sympathetic reflexes.

Structured PICO

Does right atrial receptor stimulation reduce renal sympathetic nerve activity via GABA in the paraventricular nucleus in anaesthetised Wistar rats?

Population

Anaesthetised Wistar rats

Intervention

Right atrial receptor stimulation via balloon inflation at the right vena cava-atrium junction, with microinjections of neurotransmitter antagonists (bicuculline, L-NAME, L-NMMA) into the paraventricular nucleus (PVN) or intrathecal SCH 23390

Comparator

Baseline control (before application of neurotransmitter antagonists)

Outcome

Renal sympathetic nerve activity (RSNA)surrogate

Atrial receptor activation inhibits renal sympathetic nerve activity at the paraventricular nucleus through a GABA-mediated mechanism in rats.

Cite This Study

Yang et al. (2003) studied this question.

synapsesocial.com/papers/6a8bcf040ca85c7e33df0df4 https://doi.org/10.1113/eph8802561

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Role of GABA and NO in the Paraventricular Nucleus‐Mediated Reflex Inhibition of Renal Sympathetic Nerve Activity Following Stimulation of Right Atrial Receptors in the Rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Role of GABA and NO in the Paraventricular Nucleus‐Mediated Reflex Inhibition of Renal Sympathetic Nerve Activity Following Stimulation of Right Atrial Receptors in the Rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider