Key result
Microinjection of muscimol into the PVN abolished the reduction in renal sympathetic nerve activity normally elicited by volume expansion, whereas L-NAME had no effect.
The hypothalamic paraventricular nucleus is essential in the central pathways mediating the renal sympathetic nerve response to plasma volume elevations, independent of nitric oxide.
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PVN mediates volume-induced renal sympathoinhibition in rodents; leaves open translation to human cardiorenal therapies.
Ng et al. (2004) studied this question. Muscimol and L-NAME vs. Vehicle and microinjections outside the PVN was evaluated on Reduction in renal sympathetic nerve activity (RSNA) elicited by volume expansion. Microinjection of muscimol into the PVN abolished the reduction in renal sympathetic nerve activity normally elicited by volume expansion, whereas L-NAME had no effect.
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