March 1, 2000Experimental PhysiologyOpen Access

Paraventricular neurones elicit a volume expansion-like change of activity in sympathetic nerves to the heart and kidney in the rabbit

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Population

Anaesthetised rabbits

Design

Preclinical

Authors

JDJennifer DeeringUniversity Health Network

Discussion

Member takes

Implication

PVN-driven differential sympathetic patterning supports a central role in volume regulation; leaves open translation to human HF or hypertension.

Structured PICO

Population

Anaesthetised rabbits

Intervention

Activation of paraventricular nucleus (PVN) neurones by discrete injections (25-100 nl) of d,l-homocysteic acid (DLH, 0.2 M)

Outcome

Changes in sympathetic nerve activity (renal, inferior cardiac, splanchnic, and adrenal nerves) and pressor responsesurrogate

The paraventricular nucleus can evoke a differential pattern of sympathetic discharge that mimics the response to acute blood volume expansion, suggesting its role in blood volume regulation.

Cite This Study

Jennifer Deering (2000) studied this question.

synapsesocial.com/papers/6a87c616f762332bf8fe7d3e https://doi.org/10.1017/s0958067000019539

View Full Paper

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Implication

PVN-driven differential sympathetic patterning supports a central role in volume regulation; leaves open translation to human HF or hypertension.

Paraventricular neurones elicit a volume expansion-like change of activity in sympathetic nerves to the heart and kidney in the rabbit

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Paraventricular neurones elicit a volume expansion-like change of activity in sympathetic nerves to the heart and kidney in the rabbit

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider