Key result
Microinjection of glycine or kynurenic acid into the RVLM of Goldblatt hypertensive rats significantly decreased mean arterial blood pressure, while L-glutamate increased it (P<0.05).
Why the study?
Does modulation of the rostral ventrolateral medulla alter mean arterial blood pressure in rats with Goldblatt hypertension?
Population
Rats with renovascular Goldblatt (two-kidney, one clip) hypertension and normotensive control rats (n=46)
Comparison
Bilateral microinjection of glycine… vs Normotensive rats receiving the same…
Design
Preclinical
Authors
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Supports RVLM amino acid signaling in renovascular hypertension models; hypothesis-generating and leaves open translation to human therapy.
Does modulation of the rostral ventrolateral medulla alter mean arterial blood pressure in rats with Goldblatt hypertension?
p-value: p=<.05
The rostral ventrolateral medulla plays a crucial role in maintaining elevated blood pressure in renovascular Goldblatt hypertension, mediated in part by glutamatergic transmission.
Bergamaschi et al. (1995) studied Renovascular Goldblatt hypertension (n=46). Microinjection of glycine, L-glutamate, or kynurenic acid into the RVLM vs. Normotensive rats / baseline was evaluated on Mean arterial blood pressure (MAP) (p=<.05). Microinjection of glycine or kynurenic acid into the RVLM of Goldblatt hypertensive rats significantly decreased mean arterial blood pressure, while L-glutamate increased it (P<0.05).
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