What is the clinical evidence from this study?

Study design: Case Report. Population: Marfan's syndrome (n=2). Intervention: Necropsy. Primary outcome: Pathology of cardiac conduction system.

What question did this study set out to answer?

To examine histopathological abnormalities within the cardiac conduction system of patients with Marfan syndrome who suffered fatal rhythm disturbances.

September 1, 1964Archives of Internal Medicine

Pathology of Cardiac Conduction System in Marfan's Syndrome

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Key result

Necropsy of two young men with Marfan's syndrome and terminal arrhythmias was performed to evaluate the pathology of their cardiac conduction system.

Population

2 young men with Marfan's syndrome who developed disturbances in cardiac rhythm or conduction during their…

Design

Case_series

Authors

TJThomas N. JamesTulane University

Discussion

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Implication

May support arrhythmia surveillance in Marfan syndrome; leaves open causal role of conduction pathology in sudden death.

Key Points

To examine histopathological abnormalities within the cardiac conduction system of patients with Marfan syndrome who suffered fatal rhythm disturbances.
Conducted post-mortem histopathological examinations (necropsy) of the cardiac conduction system in two young male patients (N=2) with Marfan syndrome.
Correlated terminal clinical cardiac rhythm and conduction disorders with post-mortem anatomical findings.
Demonstrated marked structural and pathological changes within the specialized cardiac conduction pathways at necropsy in both patients.
Confirmed severe cardiovascular and characteristic musculoskeletal manifestations, including profound thoracic deformity and arachnodactyly, associated with terminal arrhythmias.

Study Design

Type

Case Report (n=2)

Structured PICO

Population

Two young men with Marfan's syndrome who developed disturbances in cardiac rhythm or conduction during their terminal illness.

Outcome

Pathology of the cardiac conduction system at necropsy

This case series describes the pathology of the cardiac conduction system in two young men with Marfan's syndrome who experienced terminal arrhythmias.

Cite This Study

Thomas N. James (1964) conducted a case report in Marfan's syndrome (n=2). Necropsy was evaluated on Pathology of cardiac conduction system. Necropsy of two young men with Marfan's syndrome and terminal arrhythmias was performed to evaluate the pathology of their cardiac conduction system.

synapsesocial.com/papers/6a656dfbebc568ad1c2d6d22 https://doi.org/10.1001/archinte.1964.03860090073006

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Pathology of Cardiac Conduction System in Marfan's Syndrome

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Pathology of Cardiac Conduction System in Marfan's Syndrome

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

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