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July 1, 1980Acta Physiologica Scandinavica

Effects of castration and testosterone substitution on body composition and muscle metabolism in rats

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MKM KrotkiewskiUniversity of Gothenburg JKJohn G. KralVassar College JKJ. KarlssonLinköping University

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Implication

Randomized trial examines how castration and testosterone affect body weight and muscle in rats, suggesting hormonal influence on physical development.

Key Points

This research aims to investigate the impact of castration and testosterone substitution on body composition and muscle metabolism in rats.
Male weanling Wistar rats were castrated or sham-operated and followed for 12 weeks.
Rats received no substitution or large (2 mg . 14 days-1) or small (0.2 mg . 14 days-1) doses of testosterone enantate.
The effects on body weight, adipose tissue, and muscle fiber composition were assessed.
Castration without testosterone led to lower body weight and smaller fat cell sizes, especially in epididymal and caudal subcutaneous depots.
Fast-twitch high-oxidative (type II A) muscle fibers decreased in castrated rats without testosterone.
Activities of phosphorylase and lactate dehydrogenase in the gastrocnemius muscle decreased in castrates but were restored by the large testosterone dose.

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Krotkiewski et al. (1980) studied this question.

synapsesocial.com/papers/6a6578fffd26db5682d78376 https://doi.org/10.1111/j.1748-1716.1980.tb06592.x

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Implication

Randomized trial examines how castration and testosterone affect body weight and muscle in rats, suggesting hormonal influence on physical development.

Effects of castration and testosterone substitution on body composition and muscle metabolism in rats

Discussion

Member takes

Implication

Key Points

Cite This Study

Effects of castration and testosterone substitution on body composition and muscle metabolism in rats

Discussion

Member takes

Implication

Key Points

Cite This Study

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