Key result
The 5'-terminus of poliovirion RNA consists of a protein covalently linked to the nucleotide sequence pU-U-A-A-A-A-C-A-G, which may act as a primer for initiating viral RNA synthesis.
The identification of a covalently linked protein at the 5'-terminus of poliovirus RNA provides foundational evidence that a protein-nucleotide structure acts as a primer for viral RNA synthesis.
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Protein at poliovirion RNA 5' end; leaves open functional role in replication pending targeted studies.
Flanegan et al. (1977) studied Poliovirus. Biochemical analysis of poliovirus RNA was evaluated on 5'-terminus structure of poliovirion RNA. The 5'-terminus of poliovirion RNA consists of a protein covalently linked to the nucleotide sequence pU-U-A-A-A-A-C-A-G, which may act as a primer for initiating viral RNA synthesis.
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