July 26, 2026Circulation135 citationsOpen Access
View Full PaperUnlocking the Secrets of Mitochondria in the Cardiovascular System
Key Points
- This research aims to explore the impact of mitochondria on heart failure and identify potential therapies.
- Expert workshop convened by the National Heart, Lung, and Blood Institute in August 2018
- Review of current scientific literature regarding mitochondria in cardiovascular diseases
- Recommendations for clinical strategies targeting mitochondrial dysfunction
- Identified key gaps in current research on mitochondria and cardiovascular diseases
- Proposed both short- and long-term approaches for developing mitochondria-based therapies
- Emphasized the need for translational and clinical research advancements in this field
Abstract
Mitochondria have emerged as a central factor in the pathogenesis and progression of heart failure, and other cardiovascular diseases, as well, but no therapies are available to treat mitochondrial dysfunction. The National Heart, Lung, and Blood Institute convened a group of leading experts in heart failure, cardiovascular diseases, and mitochondria research in August 2018. These experts reviewed the current state of science and identified key gaps and opportunities in basic, translational, and clinical research focusing on the potential of mitochondria-based therapeutic strategies in heart failure. The workshop provided short- and long-term recommendations for moving the field toward clinical strategies for the prevention and treatment of heart failure and cardiovascular diseases by using mitochondria-based approaches.