Key result
The K+ channel regulating resting membrane potential in the ovine pulmonary circulation changes after birth from a Ca2+-dependent K+ channel to a voltage-dependent K+ channel.
The transition of pulmonary circulation resistance at birth is associated with a maturational shift in pulmonary K+ channels from Ca2+-sensitive to voltage-dependent.
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Provides foundational electrophysiology data on ovine PASMCs; leaves open the role of O2-sensitive K+ channels in human neonatal pulmonary transition.
Reeve et al. (1998) studied this question. Developmental stage (fetal vs adult) was evaluated on Resting membrane potential and K+ channel activity. The K+ channel regulating resting membrane potential in the ovine pulmonary circulation changes after birth from a Ca2+-dependent K+ channel to a voltage-dependent K+ channel.
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