Population
Vascular smooth muscle (VSM) myocytes from adult and near-term fetal sheep cerebral (basilar) arteries
Comparison
Assessment of voltage-gated K+ channel function… vs Adult sheep cerebral artery VSM myocytes
Design
Preclinical
Authors
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May explain developmental vascular contractility differences; leaves open translation to human perinatal hemodynamics.
Fetal cerebral artery myocytes have higher BKCa current densities than adult myocytes due to a lower calcium set point, which may explain developmental differences in vascular contractility.
Lin et al. (2003) studied this question.
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