January 8, 2013The Journal of PhysiologyOpen Access

Mechanisms underlying regional differences in the Ca2+sensitivity of BKCacurrent in arteriolar smooth muscle

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Population

Cerebral and cremaster vascular smooth muscle cells (VSMCs)

Comparison

β1-subunit-directed siRNA vs Control/untreated cells and comparison between…

Design

Preclinical

Authors

YYYan YangShandong Provincial Hospital YSYoshiro SohmaInternational University of Health and Welfare ZNZahra NourianUniversity of Missouri

Discussion

Member takes

Implication

Differential BKCa Ca2+ sensitivity may underlie regional vasomotor control; hypothesis-generating for β1-subunit targeting pending human studies.

Structured PICO

Population

Cerebral and cremaster vascular smooth muscle cells (VSMCs)

Intervention

β1-subunit-directed siRNA

Comparator

Control/untreated cells and comparison between cerebral and cremaster VSMCs

Outcome

Ca2+ sensitivity and normalized open probability (NPo) of BKCa channelssurrogate

Cerebral vascular smooth muscle cells exhibit higher Ca2+ sensitivity and open probability for BKCa channels compared to skeletal muscle, driven by a higher ratio of β1-subunit to α-subunit.

Cite This Study

Yang et al. (2013) studied this question.

synapsesocial.com/papers/6a88f7ba6ef699e80f1feeb7 https://doi.org/10.1113/jphysiol.2012.241562

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Implication

Differential BKCa Ca2+ sensitivity may underlie regional vasomotor control; hypothesis-generating for β1-subunit targeting pending human studies.

Mechanisms underlying regional differences in the Ca2+sensitivity of BKCacurrent in arteriolar smooth muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanisms underlying regional differences in the Ca2+sensitivity of BKCacurrent in arteriolar smooth muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider