Key result
Serum AGP1 combined with urinary extracellular vesicle miR-21-5p accurately discriminated primary aldosteronism from essential hypertension and normotensive controls with an AUC of 0.94.
Why the study?
Primary aldosteronism is the most common cause of secondary hypertension with a broad-spectrum phenotype, prompting the need to evaluate lipocalins and urinary extracellular vesicle microRNAs as novel biomarkers.
Do serum AGP1 and urinary EV miR-21-5p accurately discriminate primary aldosteronism from essential hypertension and normotension in adult subjects?
Population
41 adult subjects (normotensive controls, essential hypertensives, and primary aldosteronism)
Comparison
Primary aldosteronism vs essential hypertension vs normotensive controls
Design
Cross-sectional study
Authors
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May support biomarker discovery in PA; leaves open diagnostic utility pending prospective validation.
Cross-Sectional (n=41)
Do serum AGP1 and urinary EV miR-21-5p accurately discriminate primary aldosteronism from essential hypertension and normotension in adult subjects?
Effect estimate: AUC 0.94 (95% CI 0.85-1.00)
p-value: p=<0.001
Serum AGP1 and urinary EV miR-21-5p demonstrate high discriminatory capacity and may serve as novel biomarkers for identifying primary aldosteronism.
Carvajal et al. (2021) conducted a cross-sectional in Primary Aldosteronism (n=41). Serum AGP1 and uEV miR-21-5p vs. Essential hypertensives and normotensive controls was evaluated on Discriminatory capacity (AUC) for Primary Aldosteronism (AUC 0.94, 95% CI 0.85-1.00, p=<0.001). Serum AGP1 combined with urinary extracellular vesicle miR-21-5p accurately discriminated primary aldosteronism from essential hypertension and normotensive controls with an AUC of 0.94.
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