Key result
Single 5-mg oral doses of ramipril or enalapril did not significantly change regional cerebral blood flow compared to placebo in hypertensive patients with >=70% internal carotid artery stenosis.
Why the study?
Does a single 5-mg oral dose of ramipril or enalapril reduce regional cerebral blood flow in elderly asymptomatic hypertensive patients with >= 70% internal carotid artery stenosis?
RCT (n=15)
single-blind
randomized
Does a single 5-mg oral dose of ramipril or enalapril reduce regional cerebral blood flow in elderly asymptomatic hypertensive patients with >= 70% internal carotid artery stenosis?
Single 5-mg starting doses of ramipril or enalapril do not significantly decrease cerebral blood flow in elderly hypertensive patients with severe asymptomatic carotid stenosis, suggesting they are safe to initiate in this population.
Authors
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May support short-term ACEI safety in carotid stenosis without CBF reduction; leaves open long-term effects and larger trials.
Patel et al. (1996) conducted an RCT in asymptomatic carotid artery occlusive disease and hypertension (n=15). ramipril or enalapril vs. placebo was evaluated on change in regional cerebral blood flow (rCBF). Single 5-mg oral doses of ramipril or enalapril did not significantly change regional cerebral blood flow compared to placebo in hypertensive patients with >=70% internal carotid artery stenosis.
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