December 7, 1984Science207 citations
View Full PaperNucleotide Sequences of the Human and Mouse Atrial Natriuretic Factor Genes
Key Result
Cloning and sequencing of the human and mouse atrial natriuretic factor genes revealed highly conserved 5' flanking sequences and proANF coding regions, suggesting a role in gene regulation.
Abstract
Mouse and human atrial natriuretic factor (ANF) genes have been cloned and their nucleotide sequences determined. Each ANF gene consists of three coding blocks separated by two intervening sequences. The 5' flanking sequences and those encoding proANF are highly conserved between the two species, while the intervening sequences and 3' untranslated regions are not. The conserved sequences 5' of the gene may play an important role in the regulation of ANF gene expression.