Key result
CTRP6 promotes tumorigenesis and development in digestive system tumors through multiple mechanisms, including the release of pro-inflammatory factors, regulation of glycolipid metabolism, and promotion of tumor angiogenesis.
Why the study?
Recent studies revealed the tumor-promoting effect of CTRP6 in gastrointestinal tumors, but a systematic discussion on its tumor-promoting mechanism was lacking.
This review summarizes the tumor-promoting mechanisms of CTRP6 in gastrointestinal cancers.
Answers are grounded in this paper and cite their sources.
CTRP6 may modulate digestive tumor biology via metabolic and inflammatory pathways; leaves open its value as biomarker or target pending validation.
Tumors of the digestive system have always received attention, and their occurrence and development are regulated by various mechanisms such as inflammation and immunity, glucose and lipid metabolism, and tumor angiogenesis. Complement Clq/TNF-related protein 6 (CTRP6) is a member of the CTRP family; it is widely expressed in various tissues and cell types, and plays a biological role in a number of mechanisms, such as glucose and lipid metabolism and inflammation. Recent studies have revealed the tumor-promoting effect of CTRP6 in gastric cancer, liver cancer, colorectal cancer and other gastrointestinal tumors, but, to the best of our knowledge, there has been no systematic discussion on the tumor-promoting mechanism of CTRP6. The present study reviews the role of CTRP6 in tumors of the digestive system and its possible mechanisms.
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Zhang et al. (2022) conducted a review in Digestive system tumors. CTRP6 was evaluated. CTRP6 promotes tumorigenesis and development in digestive system tumors through multiple mechanisms, including the release of pro-inflammatory factors, regulation of glycolipid metabolism, and promotion of tumor angiogenesis.
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