March 1, 2016Physiological ReportsOpen Access

Immunomodulatory roles of CTRP3 in endotoxemia and metabolic stress

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Population

Genetic mouse models (wild-type, CTRP3 deficiency, and CTRP3 overexpression transgenic mice)

Comparison

Acute and chronic inflammatory stimuli vs Wild-type mice; matched control low-fat diet

Design

Preclinical

Authors

PPPia S. PetersenGubra (Denmark)RWRisa M. WolfRutgers, The State University of New Jersey XLXia LeiOklahoma State University

Discussion

Member takes

Implication

CTRP3 may selectively modulate inflammation in obesity models; leaves open therapeutic relevance pending human studies.

Structured PICO

Population

Genetic mouse models (wild-type, CTRP3 deficiency, and CTRP3 overexpression transgenic mice)

Intervention

Acute (sublethal dose of LPS challenge) and chronic (high-fat diet) inflammatory stimuli

Comparator

Wild-type mice; matched control low-fat diet

Outcome

Serum cytokine and chemokine levels (including IL-1β, IL-6, TNF-α, MIP-2, and 71 serum cytokines)surrogate

CTRP3 exhibits a context-dependent immunomodulatory role, attenuating systemic inflammation in the setting of obesity and insulin resistance but not during acute LPS challenge.

Cite This Study

Petersen et al. (2016) studied this question.

synapsesocial.com/papers/6a832e4d88eff2bd7befecf6 https://doi.org/10.14814/phy2.12735

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