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CTRP6 acts as a positive regulator of inflammatory cascades and a negative regulator of adipogenesis and adipose tissue expansion in mice.
CTRP6 acts as an early responder to acute nutritional changes, promoting inflammation and limiting adipose tissue expansion in mice.
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Does not inform clinical practice; hypothesis-generating for CTRP6 in metabolic models.
CTRP6 (C1qTNF6), a member of adiponectin gene family, regulates inflammation and metabolism in established obesity. Here, short-term high-fat feeding in mice is shown to increase adipose tissue expression of CTRP6 before changes in the expression of classical inflammatory genes occur. Conversely, CTRP6 expression in adipose tissue decreases early in the course of obesity reversal. Gain- and loss-of-function models suggest CTRP6 as a positive regulator of inflammatory cascades, and a negative regulator of adipogenesis and adipose tissue expansion.
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Lahav et al. (2021) studied Obesity and adipose tissue inflammation. CTRP6 gain- and loss-of-function was evaluated on Adipose tissue expression of CTRP6, inflammation, and adipogenesis. CTRP6 acts as a positive regulator of inflammatory cascades and a negative regulator of adipogenesis and adipose tissue expansion in mice.
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