Key result
Gadolinium significantly reduced the ratio of premature ventricular contractions induced by acute left ventricular pressure overloading in a dose-dependent manner, from 0.24 to 0.10 at the highest dose.
Why the study?
Does gadolinium suppress stretch-induced increases in spatial dispersion of repolarization and ventricular arrhythmias in anesthetized dogs?
Does gadolinium suppress stretch-induced increases in spatial dispersion of repolarization and ventricular arrhythmias in anesthetized dogs?
Absolute Event Rate: 0.1% vs 0.24%
p-value: p=<0.01
Gadolinium, a stretch-activated channel blocker, suppresses stretch-induced spatial dispersion of repolarization and ventricular arrhythmias in a canine model, independent of calcium channel blockade.
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Acute LV overload may promote arrhythmias via regional repolarization differences; leaves open stretch-activated channel role in humans.
Takagi et al. (1999) studied Stretch-induced ventricular arrhythmias (n=17). Gadolinium (Gd3+) vs. Control (aortic clamping without gadolinium) was evaluated on Arrhythmic ratio (premature ventricular contraction counts divided by total beat counts during aortic clamping) (p=<0.01). Gadolinium significantly reduced the ratio of premature ventricular contractions induced by acute left ventricular pressure overloading in a dose-dependent manner, from 0.24 to 0.10 at the highest dose.
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