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July 26, 2026ACS Sensors

Overcoming Liquid Biopsy Barriers: Nucleic Acid Biosensors Integrating DNA Nanotechnology and CRISPR−Cas System for Cancer Precision Theranostics

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Authors

YLYutong LvKKulsoomLJLijun Jia

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Overview

Review analyzes biosensor strategies to enhance liquid biopsy sensitivity for cancer detection, suggesting implications for clinical use.

Key Points

  • This review aims to address the limitations of liquid biopsies in cancer detection and propose innovative biosensor designs.
  • Analysis of three biosensor categories: functional DNA nanostructures, CRISPR-Cas systems, and synthetic analogues.
  • Exploration of structural and enzymatic optimization techniques to enhance sensitivity and robustness.
  • Discussion of strategies for clinical translation, including microfluidics and artificial intelligence support.
  • Achieved attomolar-level detection of low-abundance cancer biomarkers through advanced biosensor designs.
  • Identified key challenges in clinical applicability, such as biological variability and probe degradation.
  • Outlined innovative approaches to improve clinical utility, including theranostic applications and enhanced data analysis.

Cite This Study

Lv et al. (2026) studied this question.

synapsesocial.com/papers/6a65a36cd3aea3239cd768behttps://doi.org/10.1021/acssensors.6c01673
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