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This study aims to characterize phenolic compounds in Dittrichia viscosa and evaluate their bioactivity.

July 26, 2026PharmaceuticalsOpen Access

Multi-Target Bioactivity of Dittrichia viscosa Polyphenols: HPLC-ESI-MS Profiling, Antimicrobial Mechanisms, and Molecular Docking

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Randomized trial evaluates bioactivity of Dittrichia viscosa extracts, suggesting potential for pharmaceutical applications.

This study aims to characterize phenolic compounds in Dittrichia viscosa and evaluate their bioactivity.
Characterized extracts using ICP-AES and HPLC-PDA-ESI-MS for phenolic content analysis.
Assessed antioxidant capacity with DPPH, ABTS, FRAP, and ORAC assays.
Tested antibacterial and antifungal activity, employing membrane integrity assays and molecular docking against various targets.
Methanolic extract had 55.05 mg GAE/g phenolics and a DPPH IC50 of 0.090 mg/mL, indicating strong antioxidant capacity.
Antibacterial activity reached an MIC of 0.25–1 mg/mL with 88% inhibition of Trichophyton rubrum mycelium.
Molecular docking ranked kaempferol-3-O-pentoside with a binding energy of -10.3 kcal/mol, indicating significant interaction potential.

Abdelfattah et al. (2026) studied this question.

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