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July 26, 2026European Journal of HistochemistryOpen Access

Histopathological evaluation of RPL5 expression in triple-negative breast cancer: an integrated immunohistochemical and transcriptomic study

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Authors

BZBing ZhaoPYPeiyuan YuLLLi Li

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Overview

Randomized trial investigates RPL5 expression in triple-negative breast cancer, suggesting its relevance in cancer biology.

Key Points

  • This study aims to examine the expression of RPL5 in triple-negative breast cancer (TNBC) and its potential biological implications.
  • Immunohistochemical evaluation of RPL5 expression in 37 TNBC tissues and 7 adjacent normal tissues.
  • Analysis of public transcriptomic datasets from TCGA-BRCA and GEO to validate RPL5 expression patterns.
  • Functional enrichment analyses were conducted, focusing on ribosome biogenesis and p53 signaling pathways.
  • Immunohistochemistry revealed significantly lower RPL5 expression in TNBC tissues compared to adjacent normal tissues (p=0.001).
  • Transcriptomic analyses showed significantly higher RPL5 expression in TNBC versus non-TNBC subtypes (p<0.001).
  • Survival analysis indicated no significant difference in overall survival based on RPL5 expression levels (all p>0.05).

Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/6a65a501d3aea3239cd7752bhttps://doi.org/10.4081/ejh.2026.4599
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