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September 5, 2025Diagnostic PathologyOpen Access

Prognostic impact of RPL15 overexpression in intrahepatic cholangiocarcinoma: a marker of aggressive tumor behavior

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Authors

WWWen‐Ching WangCalifornia Institute of TechnologyCHChien‐Jui HuangNational Taiwan UniversityHHHan-Ping HsuChi Mei Medical Center

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Overview

Observational analysis found RPL15 overexpression predicts worse disease-specific and local recurrence-free survival in intrahepatic cholangiocarcinoma, suggesting a need for targeted therapies.

Key Points

  • High RPL15 expression was linked to advanced tumor stage and poor disease-specific survival rates.
  • Univariate analyses revealed RPL15 overexpression significantly predicted worse local recurrence-free and metastasis-free survival outcomes.
  • Multivariate analyses confirmed RPL15 as an independent prognostic factor for disease-specific and local recurrence-free survival.
  • RPL15 presents a potential therapeutic target for developing treatment strategies in aggressive intrahepatic cholangiocarcinoma.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68bb49d26d6d5674bccfffbchttps://doi.org/10.1186/s13000-025-01699-y
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