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July 26, 2026BMC Medical ImagingOpen Access

Multiparametric MRI with DWI, SWI, and DSC-PWI for preoperative prediction of Ki-67, IDH, and ATRX in adult-type diffuse gliomas

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Authors

MKMuhammet Arif KurşunBBBegümhan BaysalGAGulnihal Ay

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Overview

Retrospective study evaluates multiparametric MRI to predict Ki-67 and molecular features in diffuse gliomas, suggesting potential for preoperative tumor characterization.

Key Points

  • Evaluate the associations of multiparametric MRI features with Ki-67 index, IDH status, and ATRX expression in adult-type diffuse gliomas.
  • Retrospective analysis of 126 adult-type diffuse glioma patients with MRI, DWI, SWI, and DSC-PWI.
  • Quantitative ADC and rCBV measurements performed by two independent readers.
  • ROC analysis for diagnostic performance of MRI parameters regarding Ki-67 expression and WHO grade.
  • 84.1% of patients had WHO grade 4 tumors; significant differences in ADC and rCBV metrics associated with high Ki-67 expression.
  • High Ki-67 expression correlated with necrosis, edema, and enhancement patterns.
  • rCBVmax demonstrated the highest diagnostic performance for high Ki-67 expression (AUC = 0.967; 95% CI: 0.920–1.000).

Cite This Study

Kurşun et al. (2026) studied this question.

synapsesocial.com/papers/6a65a5bad3aea3239cd778b3https://doi.org/10.1186/s12880-026-02607-6
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Also Consider

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  1. 1Time-dependent diffusion-weighted imaging assessment of tumor grading and isocitrate dehydrogenase genotypes in adult-type diffuse gliomas2026
  2. 2Noninvasive assessment of Ki-67 labeling index in glioma patients based on multi-parameters derived from advanced MR imaging2024 · 3 citations
  3. 3Optimized Time-Dependent Diffusion MRI for Preoperative Molecular Subtyping of Adult Diffuse Gliomas2026
  4. 4The impact of diffusion and perfusion-weighted imaging on glioma grading2024 · 1 citations
  5. 5Apparent diffusion coefficient metrics for adult-type diffuse gliomas classified according to WHO 2021: a systematic review2026