What does this research mean for the field?

Apparent diffusion coefficient (ADC) metrics can serve as noninvasive imaging biomarkers for characterizing adult-type diffuse gliomas, but their stand-alone diagnostic utility is currently limited by methodological heterogeneity and overlapping values across tumor subtypes. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the associations between apparent diffusion coefficient (ADC) measurements and the molecular and histological subtypes of adult-type diffuse gliomas defined by the 2021 WHO CNS5 classification.

August 30, 2026The Egyptian Journal of Radiology and Nuclear MedicineOpen Access

Apparent diffusion coefficient metrics for adult-type diffuse gliomas classified according to WHO 2021: a systematic review

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Authors

DMDragos Gabriel MargalinCarol Davila University of Medicine and Pharmacy RSRăzvan StănciulescuCarol Davila University of Medicine and Pharmacy DBDidina-Catalina BarbalataCarol Davila University of Medicine and Pharmacy

Discussion

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Implication

Systematic review reveals lower apparent diffusion coefficient values in aggressive adult-type diffuse gliomas, highlighting its biomarker potential alongside limits from methodological variation.

Key Points

To evaluate the associations between apparent diffusion coefficient (ADC) measurements and the molecular and histological subtypes of adult-type diffuse gliomas defined by the 2021 WHO CNS5 classification.
Conducted a systematic review following PRISMA 2020 guidelines across PubMed, Scopus, Cochrane, and Google Scholar up to December 2025, assessing quality using QUADAS-2.
Identified 15 eligible studies comprising 1,706 adult-type diffuse glioma patients with quantitative ADC data, using a structured narrative synthesis due to methodological heterogeneity.
IDH-wildtype gliomas exhibited the lowest ADC measurements (0.78–1.48 × 10⁻³ mm²/s), and an inverse correlation was observed between histological tumor grade and ADC values.
Mean ADC sensitivity for determining IDH mutation status ranged from 65.4% to 85.9%, while diagnostic specificity varied widely from 35.0% to 91.4%.

Cite This Study

Margalin et al. (2026) studied this question.

synapsesocial.com/papers/6a93f1176c1a8fb52e79dba2 https://doi.org/10.1186/s43055-026-01847-4

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Implication

Systematic review reveals lower apparent diffusion coefficient values in aggressive adult-type diffuse gliomas, highlighting its biomarker potential alongside limits from methodological variation.

Apparent diffusion coefficient metrics for adult-type diffuse gliomas classified according to WHO 2021: a systematic review

Discussion

Member takes

Implication

Key Points

Cite This Study

Apparent diffusion coefficient metrics for adult-type diffuse gliomas classified according to WHO 2021: a systematic review

Discussion

Member takes

Implication

Key Points

Cite This Study

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