Key result
Vascular stiffness in older premenopausal female monkeys increased progressively down the aortic tree, with the greatest increases observed in the iliac artery.
Why the study?
Prior work on vascular stiffness down the aortic tree mainly studied short-lived rodents that do not undergo menopause.
Observational
Suggests regional aortic heterogeneity in premenopausal vascular aging; leaves open clinical translation and targeted interventions.
This is the first study to examine vascular stiffness down the aortic tree in aging premenopausal females (24 ± 0.7 yr old), whereas prior work studied mainly rodents, which are short-lived and do not undergo menopause. Histological mechanisms mediating vascular stiffness in older premenopausal females increased progressively down the aortic tree, with greater increases in the abdominal aorta compared with the thoracic aorta and with the greatest increases and differences observed in the iliac artery.
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Babici et al. (2020) conducted an observational in Vascular stiffness. Aging was evaluated on Vascular stiffness down the aortic tree. Vascular stiffness in older premenopausal female monkeys increased progressively down the aortic tree, with the greatest increases observed in the iliac artery.
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