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This study aims to analyze the pharmacokinetics of enrofloxacin and ciprofloxacin in dogs and assess PK/PD target attainment.

July 26, 2026AntibioticsOpen Access

Exploratory Pharmacokinetic Characterization of Enrofloxacin and Ciprofloxacin in Plasma and Interstitial Fluid of Dogs: Nonlinear Mixed-Effects Modeling and PK/PD Target Attainment Analysis

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Randomized trial assesses antimicrobial exposure in dogs, suggesting ISF reflects better target attainment.

This study aims to analyze the pharmacokinetics of enrofloxacin and ciprofloxacin in dogs and assess PK/PD target attainment.
Nine healthy Beagle dogs received a single oral dose of enrofloxacin (20 mg/kg).
Pharmacokinetic data collected over 24 hours from plasma and interstitial fluid (ISF) were analyzed using LC–MS/MS.
Monte Carlo simulations were performed for probability of target attainment (PTA) across various MICs.
Mean AUC0–24 was significantly higher in ISF than in plasma (44.9 vs. 21.6 µg × h/mL).
PTA for enrofloxacin was higher in ISF than in plasma, with a higher MIC for ≥90% PTA in ISF (0.125 vs. 0.03 µg/mL).
Exploratory pharmacokinetic models effectively described concentration-time data for both plasma and ISF.

Mag et al. (2026) studied this question.

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July 26, 2026AntibioticsOpen Access

View Full Paper

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Authors

Randomized trial assesses antimicrobial exposure in dogs, suggesting ISF reflects better target attainment.

This study aims to analyze the pharmacokinetics of enrofloxacin and ciprofloxacin in dogs and assess PK/PD target attainment.
Nine healthy Beagle dogs received a single oral dose of enrofloxacin (20 mg/kg).
Pharmacokinetic data collected over 24 hours from plasma and interstitial fluid (ISF) were analyzed using LC–MS/MS.
Monte Carlo simulations were performed for probability of target attainment (PTA) across various MICs.
Mean AUC0–24 was significantly higher in ISF than in plasma (44.9 vs. 21.6 µg × h/mL).
PTA for enrofloxacin was higher in ISF than in plasma, with a higher MIC for ≥90% PTA in ISF (0.125 vs. 0.03 µg/mL).
Exploratory pharmacokinetic models effectively described concentration-time data for both plasma and ISF.

Mag et al. (2026) studied this question.

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