Investigation reveals dose-dependent pharmacokinetics of enrofloxacin and ciprofloxacin in calves, suggesting implications for safety and efficacy.
of CIP increased in a dose-dependent manner (p < 0.05), but no alteration was found in the conversion ratio of ENR to CIP (26%-28%, p > 0.05). The results of the current investigation demonstrated that the pharmacokinetics of ENR and CIP in calves had considerable variability with dose. Assessing dose-dependent pharmacokinetic alterations in calves can aid in establishing the dosing regimen; however, additional research is required to confirm dose-dependent therapeutic efficacy and safety.
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Üney et al. (2026) studied this question.
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