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August 15, 2025

Pharmacokinetics of Enrofloxacin and Its Metabolite Ciprofloxacin in Black Rockfish (Sebastes schlegelii) Following a Single Oral Administration at Two Water Temperatures.

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Authors

JBJun Sung BaeCLChae Won LeeCYChuanyan Yang

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Overview

This study reveals altered pharmacokinetics of enrofloxacin in black rockfish with temperature variations, suggesting tailored dosing strategies.

Key Points

  • ENR elimination half-life increased from 27.38 h to 42.01 h with higher water temperature, indicating significant temperature effects.
  • Plasma concentrations of ciprofloxacin were higher at 22°C, showcasing the influence of temperature on metabolite levels.
  • Analysis utilized a validated HPLC-MS/MS method for serum sample testing, ensuring accurate pharmacokinetic profiles.
  • Findings imply the necessity for repeated dosing to achieve optimal antibiotic therapy indices in aquaculture species.

Cite This Study

Bae et al. (2025) studied this question.

synapsesocial.com/papers/68a365560a429f797332b2bchttps://doi.org/10.1111/jvp.70019
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Also Consider

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