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July 26, 2026Cancer ScienceOpen Access

Real‐World Safety and Efficacy of Pola‐R‐ CHP in Previously Untreated DLBCL : POLASTAR Interim Analysis of 500 Patients

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Authors

TKTakahiro KumodeHSH SawaKMKohta Miyawaki

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Overview

Randomized trial evaluates efficacy and safety of Pola-R-CHP in patients with DLBCL, indicating positive outcomes for treatment.

Key Points

  • Evaluate the real-world efficacy and safety of Pola-R-CHP in Japanese patients with untreated DLBCL.
  • Multicenter, prospective observational study
  • Enrolled 485 patients aged ≥ 18 years with untreated DLBCL
  • Median age 71 years, assessing grade ≥ 3 adverse events and overall response rates.
  • Overall response rate 93.2% (95% CI 90.5-95.2) and complete response rate 83.3% (95% CI 79.6-86.5) in full analysis set.
  • Grade ≥ 3 adverse events occurred in 47.4% of patients, serious AEs in 12.6%.
  • Safety and efficacy consistent with results from POLARIX.

Cite This Study

Kumode et al. (2026) studied this question.

synapsesocial.com/papers/6a65a6f2d3aea3239cd780fdhttps://doi.org/10.1111/cas.70484
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Preliminary analysis of a multicenter study of Pola-R-CHP in untreated Japanese patients with DLBCL (POLASTAR)2025 · 1 citations
  2. 2Polatuzumab vedotin, rituximab, cyclophosphamide, doxorubicin, and prednisone (Pola-R- CHP) therapy in diffuse large B-cell lymphoma in patients aged 80 years or older: A real- world study2025
  3. 3Polatuzumab vedotin, rituximab, cyclophosphamide, doxorubicin, and prednisone (Pola-R-CHP) therapy in diffuse large B-cell lymphoma in patients aged 80 years or older: a real-world study2025 · 5 citations
  4. 4Real-world use of Pola-R-CHP for untreated diffuse large B-cell lymphoma (DLBCL): A systematic literature review2025
  5. 5A retrospective Study of pola-R-CHP regimen in treatment-naive patients with diffuse large B-cell lymphoma from northeast China2025