Finasteride prescribed for hair loss consistently leads to depression. Comment on ‘Depression risk of 5-alpha reductase inhibitors: impact of active-comparator versus non-drug user control groups on risk measurement’

Mayer Brezis

doi:10.1080/00325481.2026.2708396

July 23, 2026Postgraduate Medicine

Finasteride prescribed for hair loss consistently leads to depression. Comment on ‘Depression risk of 5-alpha reductase inhibitors: impact of active-comparator versus non-drug user control groups on risk measurement’

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Key Points

The aim is to address how different comparator groups affect the reported risk of depression associated with finasteride usage.
Discussion of study design comparing active-comparator and non-drug user control groups for depression risk measurement
Analysis of psychological effects linked to 5-alpha reductase inhibitors
Evaluation of findings from recent publications regarding depression risk
Evidence suggests finasteride is associated with increased depression risk
Comparison between groups may lead to different interpretations of increased risk
Active-comparator groups may underestimate depression risk compared to non-drug user controls

Implication

Comment discusses the measurement of depression risk from finasteride, highlighting comparisons between control groups.

Abstract

To the Editor,We would like to discuss the recent publication ‘Depression risk of 5-alpha reductase inhibitors: impact of active-comparator versus non-drug user control groups on risk measurement’ ...

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Cite This Study

Mayer Brezis (2026) studied this question.

synapsesocial.com/papers/6a65a76fd3aea3239cd78364 https://doi.org/10.1080/00325481.2026.2708396

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Finasteride prescribed for hair loss consistently leads to depression. Comment on ‘Depression risk of 5-alpha reductase inhibitors: impact of active-comparator versus non-drug user control groups on risk measurement’

Key Points

Implication

Abstract

Discussion

Cite This Study

Finasteride prescribed for hair loss consistently leads to depression. Comment on ‘Depression risk of 5-alpha reductase inhibitors: impact of active-comparator versus non-drug user control groups on risk measurement’

Key Points

Implication

Abstract

Discussion

Cite This Study

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