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July 26, 2026MedicineOpen Access

HALP score: A powerful and promising index for predicting prognosis among hypertension adults

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Authors

MDMin DengThe Affiliated Yongchuan Hospital of Chongqing Medical UniversityQWQian WuChinese Academy of Medical Sciences & Peking Union Medical CollegeDLDongliang LiuLuohe Medical College

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Overview

Linked-mortality cohort analysis assesses HALP score's impact on mortality outcomes in hypertensive adults, suggesting clinical importance.

Key Points

  • To evaluate the HALP score's effectiveness in predicting mortality outcomes among hypertensive adults.
  • Linked-mortality cohort analysis of 20,256 hypertensive adults from the National Health and Nutrition Examination Survey 1999-2018.
  • HALP score calculated using hemoglobin, albumin, lymphocyte, and platelet levels.
  • Cox regression analyses estimated hazard ratios for all-cause, cardiovascular, and cancer mortality.
  • Participants in the highest quartile of HALP score had a 30% reduced risk of all-cause mortality (HR = 0.70, 95% CI = 0.64–0.77, P trend < .001).
  • CVD mortality risk was 39% lower in the highest quartile (HR = 0.61, 95% CI = 0.49–0.76, P trend < .001).
  • Cancer mortality risk was 22% lower in the highest quartile (HR = 0.78, 95% CI = 0.63–0.96, P trend = .086).

Cite This Study

Deng et al. (2026) studied this question.

synapsesocial.com/papers/6a65a76fd3aea3239cd78483https://doi.org/10.1097/md.0000000000049880
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Association between the HALP Score and All-Cause and Cardiovascular Mortality in Adults with Hypertension: A NHANES Cohort Study2026 · 1 citations
  2. 2Correlation between the Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score and Left Ventricular Hypertrophy in Older Patients with Hypertension*2023 · 6 citations
  3. 3Associations of HALP score with serum prostate-specific antigen and mortality in middle-aged and elderly individuals without prostate cancer2024 · 2 citations
  4. 4Exploring the J-shaped relationship between HALP score and mortality in cancer patients: A NHANES 1999-2018 cohort study2024 · 19 citations
  5. 5Association between hemoglobin, albumin, lymphocyte, and platelet scores and all-cause and cardiovascular mortality among adults with atherosclerotic cardiovascular disease in the United States: An analysis of NHANES2025 · 4 citations