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July 26, 2026Neuropsychology ReviewOpen Access

Transdiagnostic MRI-derived Features of Psychopathology Following Traumatic Brain Injury: A Systematic Review

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Authors

ASAlexia SamiotisAHAmelia J. HicksJCJai Carmichael

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Overview

Systematic review evaluates MRI features of psychopathology following moderate-severe traumatic brain injury, suggesting dimensional frameworks for improvement.

Key Points

  • Evaluate MRI-derived features of psychopathology across diagnostic categories in moderate-severe TBI.
  • Conducted a systematic review of eligible studies investigating MRI-derived features and psychopathology in adults with TBI.
  • Screened 7,777 articles, with 18 meeting inclusion criteria, focusing on hippocampal morphology and depression.
  • Assessed risk of bias using a customized tool based on Joanna Brigg's Institute guidelines.
  • Lower hippocampal volume was associated with higher levels of depression, anxiety, apathy, and psychosis.
  • Studies showed heterogeneous findings with some morphological features converging transdiagnostically, including the hippocampus and thalamus.
  • No consistent microstructural or functional MRI features were identified across studies.

Cite This Study

Samiotis et al. (2026) studied this question.

synapsesocial.com/papers/6a65a76fd3aea3239cd7850ahttps://doi.org/10.1007/s11065-026-09709-6
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identifying a Biological Signature of Trauma-Related Neurodegeneration Following Repeated Traumatic Brain Injuries Compared with Healthy Controls2025
  2. 2Transdiagnostic neural correlates of post-traumatic stress disorder and mild traumatic brain injury2026
  3. 3Health Outcomes Following Traumatic Brain Injury: An Umbrella Review2026
  4. 4Characterising heterogeneity in brain morphology in traumatic brain injury using normative modelling2026
  5. 5Abnormal brain morphology and morphological brain network in adults with acute mild traumatic brain injury.2025 · 1 citations