Ablation outcomes in PVC-induced cardiomyopathy: A systematic review and meta-analysis stratified by site of origin
Key result
Catheter ablation improves LVEF by ~11% in PVC-induced cardiomyopathy, favoring RVOT and LVOT origins.
- Mean 11.0%
- 95% CI 9.5-12.5
- P<.001
- n=718
Why the study?
Catheter ablation is effective for PVC-induced cardiomyopathy, but whether outcomes differ by anatomical site-of-PVC origin remains unclear.
Does catheter ablation improve LVEF in patients with PVC-induced cardiomyopathy, and how do outcomes vary by site of origin?
Population
718 patients with PIC across 12 studies
Comparison
Catheter ablation outcomes stratified by anatomical site of PVC origin
Design
Systematic review and meta-analysis
Authors
Discussion
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Member takes
Implication
PVC origin influences ablation success in PIC; extends evidence for site-specific risk stratification and procedural planning.
Key Points
- This review aims to evaluate the efficacy of catheter ablation for PVC-induced cardiomyopathy and how outcomes vary by PVC origin.
- Systematic review and meta-analysis of studies from 2000 to 2025
- Included 12 studies with a total of 718 patients
- Primary outcomes were change in left ventricular ejection fraction and normalization rates.
- Ablation improved left ventricular ejection fraction by a mean of 11.0% (95% CI 9.5–12.5; P<0.001)
- Recovery of normal ejection fraction occurred in approximately 65% of patients
- Outcomes varied by PVC origin, with RVOT showing ΔLVEF ~12.5% and normalization ~70%.
Study Design
Type
Meta-Analysis (n=718)
Structured PICO
Does catheter ablation improve LVEF in patients with PVC-induced cardiomyopathy, and how do outcomes vary by site of origin?
P
Population
718 patients with PVC-induced cardiomyopathy from 12 studies evaluating catheter ablation stratified by PVC origin.
I
Intervention
Catheter ablation of premature ventricular complexes (PVCs)
O
Outcome
Change in left ventricular ejection fraction (LVEF) and normalization (≥ 50%)surrogate
Main Result
Mean Difference: 11 (95% CI 9.5–12.5)
p-value: p=<.001
Catheter ablation provides substantial and often reversible improvement in LVEF for patients with PVC-induced cardiomyopathy, though success and complication rates are highly dependent on the anatomical site of origin.
Cite This Study
Awais et al. (2026) conducted a meta-analysis in PVC-induced cardiomyopathy (n=718). Catheter ablation was evaluated on Change in LV ejection fraction (LVEF) and normalization (≥ 50%) (Mean 11.0%, 95% CI 9.5-12.5, p=<.001). Catheter ablation improved LVEF by a mean of 11.0% (95% CI 9.5-12.5; P<.001) in patients with PVC-induced cardiomyopathy, with outcomes favoring RVOT and LVOT origins.