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This review aims to elaborate on the pathological mechanisms, monitoring methods, and treatment strategies of sepsis-related immunosuppression.

July 26, 2026Critical CareOpen Access

Sepsis-related immunosuppression: a comprehensive review of current research breakthroughs

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Comprehensive review discusses immunosuppression mechanisms and treatments in sepsis, highlighting urgent clinical improvements needed.

This review aims to elaborate on the pathological mechanisms, monitoring methods, and treatment strategies of sepsis-related immunosuppression.
Systematic review of current research literature on sepsis-related immunosuppression.
Analysis of immune responses including innate and adaptive immune system dysfunctions.
Evaluation of monitoring techniques and treatment strategies for improving clinical outcomes.
Immunosuppression in sepsis leads to functional exhaustion of immune cells, affecting patient outcomes.
Treatment strategies include immunostimulation and immunomodulatory therapies, although clinical effects need further verification.
Pediatric mechanisms of immunosuppression in sepsis differ significantly from adults, warranting tailored approaches.

Ren et al. (2026) studied this question.

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