Plant‐Derived Extracts Disrupt Biofilm Formation and Quorum Sensing in Yersinia enterocolitica : Insights From GC‐MS and Molecular Docking

This study unravels the quest for phytochemicals that exhibit antibiofilm properties against Yersinia enterocolitica in the extracts of fruits of Citrus limon and Averrhoa carambola and leaves of Brassica juncea . The specific phytochemicals in the extracts were identified by GC‐MS analysis, and the findings of wet‐laboratory experiments have indicated the presence of compounds with antibiofilm activities, albeit with dose‐responsive effects. The anti‐QS activity of the compounds found in the extract was further confirmed by in silico analysis using molecular docking, which was carried out against the YenR region of Y . enterocolitica . The results showed that D‐allose, 3‐furaldehyde, and 2,4‐dihydroxy‐2,5‐dimethyl‐3(2H)‐furan‐3‐one had the highest docking scores against the 5LO7 receptor of the YenR region. In order to combat biofilms linked to Yersinia enterocolitica , natural plant products that preferentially target the specific receptors of QS could be developed using the potent abilities of protein–ligand complexes with high docking scores.