Case report identifies diagnostic challenges of foreign body granuloma in patients with pituitary adenomas, stressing the need for accurate histopathology.
Background: Foreign body granuloma of the pituitary gland is an exceptionally rare inflammatory lesion that may mimic recurrent adenoma on neuroimaging. Case Description: We report the case of a 44-year-old woman who previously underwent endonasal endoscopic surgery for a nonfunctioning pituitary adenoma and later developed a sellar mass secondary to a foreign body granulomatous reaction. Magnetic resonance imaging suggested tumor recurrence; however, gadolinium-enhanced imaging was not performed because of the patient’s known gadolinium allergy. Histopathological examination revealed xanthogranulomatous inflammation and a multinucleated giant-cell reaction to the suture material, without evidence of neoplastic recurrence. Conclusion: This case highlights the diagnostic challenges associated with postoperative sellar lesions and emphasizes the importance of histopathological confirmation in distinguishing foreign body granulomas from recurrent pituitary adenomas.
No takes yet. Share an insight, caveat, or question.
Santos et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: