Key result
Ischemia and reperfusion induced a 2-10-fold increase in the activity of Na+/H+ exchanger-directed protein kinases, including p90(rsk) and ERK1/2, in rat myocardium.
Population
Isolated rat hearts and isolated ventricular myocytes
Design
Preclinical
Authors
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In vitro ERK regulation of Na/H exchanger post-ischemia is hypothesis-generating; leaves open clinical relevance for reperfusion injury.
Effect estimate: 2-10-fold increase
MAPK-dependent pathways, including p90rsk and ERK1/2, are significantly activated during myocardial ischemia and reperfusion to regulate the Na+/H+ exchanger.
Moor et al. (2001) studied Myocardial ischemia and reperfusion. Ischemia and reperfusion was evaluated on Na+/H+ exchanger-directed protein kinase activity (2-10-fold increase). Ischemia and reperfusion induced a 2-10-fold increase in the activity of Na+/H+ exchanger-directed protein kinases, including p90(rsk) and ERK1/2, in rat myocardium.
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