August 1, 1999Journal of Biological ChemistryOpen Access

Protein Kinase-mediated Regulation of the Na+/H+ Exchanger in the Rat Myocardium by Mitogen-activated Protein Kinase-dependent Pathways

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Population

Cell extracts from adult rat hearts, cultured neonatal cardiac myocytes, and Escherichia coli expressing the…

Comparison

PD98059, serum, and endothelin 1 vs Untreated/unstimulated controls

Design

Preclinical

Authors

AMAndrea N. MoorUniversity of North Texas LFLarry FliegelUniversity of Alberta

Discussion

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Implication

Does not inform clinical pH management; leaves open MAP kinase relevance in human cardiac Na+/H+ exchange.

Structured PICO

Population

Cell extracts from adult rat hearts, cultured neonatal cardiac myocytes, and Escherichia coli expressing the carboxyl-terminal 178 amino acids of the Na+/H+ exchanger

Intervention

PD98059 (a mitogen-activated protein kinase kinase inhibitor), serum, and endothelin 1

Comparator

Untreated/unstimulated controls

Outcome

Phosphorylation of the COOH-terminal domain of the Na+/H+ exchanger and steady-state intracellular pH (pHi)surrogate

MAP kinase-dependent pathways, particularly involving p90(rsk), play an important role in regulating the Na+/H+ exchanger in the rat myocardium via endothelin-mediated stimulation.

Cite This Study

Moor et al. (1999) studied this question.

synapsesocial.com/papers/6a739b46f7b0ff0da5850655 https://doi.org/10.1074/jbc.274.33.22985

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Protein Kinase-mediated Regulation of the Na+/H+ Exchanger in the Rat Myocardium by Mitogen-activated Protein Kinase-dependent Pathways

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Protein Kinase-mediated Regulation of the Na+/H+ Exchanger in the Rat Myocardium by Mitogen-activated Protein Kinase-dependent Pathways

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider